By far the best salmon run in the state has to come out of Blue Mesa Reservoir in South West CO. They run up the Gunnison to the Taylor and East Rivers and that is where the DOW rears them for roe for hatheries. Go late September or through October and fish near, I believe it is the town of Alma or Almont, not sure. You can catch them regulary on fly fishing gear without snagging them, but action will depend on what stage of the spawn they are in. If late in the spawn the fish are pretty beat up and tired, probably ready to die and don't seem to eat much, but cathing it when the run is early and thick you will find healthy kokes eagerly ready to eat. I would throw steamers with lots of weight, often times letting it sink to the bottom and jigging it up off the bottom. You can also catch them on nymphs, but I think the take on a streamer is much more fun. You will see hundreds of fish holding in the pools, runs, eddies, etc. and you can sit in one spot all day and catch kokes. It is quite fun.